• Lions Mane

    Lion’s Mane contains over 70 bioactive ingredients and can be considered one of the most interesting mushrooms for gaining and maintaining good health. Very few mushrooms cover such a wide spectrum of therapeutic potential.

    Oriveda offers world leading formulae of Lions Mane supplement, 100% in line with all existing research: clinical, in vivo and in vitro. The key bio-actives are all specified and quantified; and their presence, percentage and bio-availability is guaranteed.







  • Oriveda's Lions Mane L+

    Oriveda's L+ is currently a combination of two separate supplements that reinforce and complement each other, and which can be mixed, dosed and balanced against each other according to your own liking.


    The L+ combi includes:

    • a full spectrum, lossless 1:1 hot water fruiting body extract, (180 capsules @ 300 mg)
    • a pharma-grade pure mycelium alcohol extract, (120 capsules @ 450 mg)

    This can cover 2 - 4 months (depending on personal dosing preferences)


    This supplement combination covers the full spectrum of Lion's Mane 's therapeutic potential.
    It is the only LM product that is truly 100% in line with all existing research: clinical, in vivo and in vitro. The key bio-actives are all specified and quantified and their presence, percentage and bioavailability is guaranteed.


    About 1:1 full spectrum lossless hot water fruiting body extract


    Includes 180 vegetable capsules @ 300 mg
    ≥ 2.5 % Terpenes
    ≥ 0.6 % Hericenones
    > 30 % Beta-glucans


    Oriveda's lossless 1:1 hot water extract contains the full Lion's Mane fruiting body in a bioavailable form. Nothing was filtered out, both soluble and insoluble bio-actives are still present in their natural synergy. In this case 'lossless' is crucial because we want the product to be 100% in line with the existing clinical research.

    Three out of the five existing human case studies were done with non-extracted dried Lion's Mane fruiting body powder; by extracting this dried powder (which we do) the bio-availability / therapeutic effect increases ± 4 - 10 times according to research, and the required dosage drops from ± 2 - 3 grams daily to ± 600 - 900 mg daily.

    Concentrated water extracts are not in line with LM research because all non-soluble matter was filtered out, including the NGF-inducing terpenes, sterols and other interesting bioactive compounds.

    The clinical studies noticed significant effects on cognition, moderate depression and anxiety. Usually hericenones are pointed out as being responsible for the NGF-inducing effects of the fruiting body. However, there is also research explicitly stating that hericenones have zero effect on cognition / NGF-induction.

    So it is possible there might be other yet unknown bioactive compounds or synergetic combinations of compounds responsible for the observed effects. It therefore makes sense to use an unfiltered (lossless) 1:1 full-spectrum extract in this case; all fruiting body compounds are present in a bioavailable form.


    About pure mycelium alcohol extract

    Includes 120 vegetable capsules @ 450 mg
    ≥ 7 % Terpenes
    ≥ 5 % Erinacines
    > 5 % Beta-Glucans
    > 2 % Polyphenols

    Oriveda 's pharmaceutical grade mycelium extract is the worlds first and (currently) the only alcohol extract based on pure liquid-grown mycelium. The emphasis is on the alcohol-soluble terpenes / terpenoids; i.e. a group of diterpenes known as erinacines. The two most recent clinical trials (2019/2020) were done using pure mycelium.

    Erinacines are seen as the most powerful NGF-inducers in Lion's Mane. They are only found in the mycelium. We have used a custom composition (a nutrients formula) for the liquid substrate in which the mycelium is growing; its purpose is to increase the production of erinacines, i.e. erinacine A.


    Click here to see the authorised 'Supplement Facts' labels with all relevant specifications.

    Click here to see the most recent third party test results.

    Quality standards

    Produced in compliance with the following quality standards :
    ISO 9001:2008, ISO 22000:2005, HACCP, cGMP
    Halal, Koosjer, USDA organic (EcoCert)

    Potential health benefits of Lions Mane

    Lion’s Mane contains over 70 bioactive ingredients and can be considered one of the most interesting mushrooms for gaining and maintaining good health. Very few mushrooms cover such a wide spectrum of therapeutic potential.


    Science has been researching Lion's Mane mushrooms for several decades now, but barely scratched the surface so far. Below we've listed the main targets in research.

    • Lion's Mane potential for Immune-modulation 
    • Anti-Gastritis and Anti-Ulcer effects
    • Balancing good and bad cholesterol
    • Anti-diabetic effects
    • Improving cognitive functions and stimulating the Nerve Growth Factor
    • Potential effects on menopausal problems, depression, anxiety

    Lions Mane & Nerve Growth Factor​

    NGF is a secreted protein that is important for the growth, maintenance, survival and regeneration of nerve cells in the human body, and is considered critical for their survival. Without it, these nerve cells / neurons will decline and die, causing both cognitive and motoric problems. The NGF was discovered in the 1950s, and in 1986 the scientists responsible received the Nobel Prize for this.

    Safety & side-effects

    There are no side effects worth mentioning. Some very sensitive people might experience mild side effects due to their genetic wiring. A minute number of people using concentrated water extracts in high dosage have reported a lessening of libido. Research has never reported such side effects.


    Caution: mushroom extracts with a high level of beta-glucans should never be used together with immune-suppressants, like those prescribed after a transplant.

    The blood sugar lowering effects can cause fatigue in those that are highly susceptible. In general these people are also very susceptible to e.g. caffeine and alcohol, or are diabetic. Taking the extract together with a sugar-containing liquid can neutralise this effect. Diabetics might have to adjust their medication; it’s best to discuss this with a medical professional.






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